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How Ironic...I'm currently knee deep in a similar issue. GMG does a greate job simulating spot colors with one caveat...if the spot channel mixes with process, all bets are off. You can dial in the spot color solids and tints (if you have colorimetric info for 1%-99% from an ink drawdown or what ever) until the delta E is negligible, but you still may have unpredictable results when the spot mix with process color. The only tool you have is the opacity percentage, which can make an improvement, but didn't go far enough for me.
How I'm currently addressing the issue is creating a multicolor target(CMYK+Spot target) printing it, creating an N-Color profile which I will then drop into GMG, utilizing an ICC workflow. Unfortunately, GMG doesn't have a proprietary solution to N-color profiling for this scenario.
Now having the acutal press print the target is the difficult part...if you can. I'm actually printing the N-Color targets on a Kodak Approval, which I think will be more accurate to the final printing in regards to the spot/process mixes, though not as accurate as an actual press. If I could go that route, I would, but it simlpy not feasable. So, there you go...not really what you wanted to hear (or what I wanted to hear either), but that's where I'm at currently.
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